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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SYK
All Species:
7.27
Human Site:
S319
Identified Species:
16
UniProt:
P43405
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43405
NP_001128524.1
635
72066
S319
N
R
Q
E
S
T
V
S
F
N
P
Y
E
P
E
Chimpanzee
Pan troglodytes
XP_520123
544
61880
P269
A
D
P
E
E
I
R
P
K
E
V
Y
L
D
R
Rhesus Macaque
Macaca mulatta
XP_001100834
635
72070
S319
N
R
P
E
S
T
V
S
F
N
P
Y
E
P
E
Dog
Lupus familis
XP_850411
644
73172
V318
K
P
G
H
R
K
P
V
P
S
S
G
S
R
P
Cat
Felis silvestris
Mouse
Mus musculus
P48025
629
71358
E318
T
V
S
F
N
P
Y
E
P
T
G
G
P
W
G
Rat
Rattus norvegicus
Q64725
629
71510
E318
T
V
S
F
N
P
Y
E
P
T
G
G
A
W
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026601
613
69811
A318
E
K
G
D
Q
R
E
A
L
P
M
D
T
E
V
Frog
Xenopus laevis
NP_001083616
609
69575
S314
N
V
E
V
T
K
E
S
M
P
M
D
T
D
V
Zebra Danio
Brachydanio rerio
NP_998008
586
67629
L311
P
Y
A
D
P
D
E
L
R
S
T
K
V
N
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24145
939
104255
S463
K
Q
K
E
N
S
S
S
M
F
N
T
L
R
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001180232
837
93621
L502
P
M
S
P
P
P
E
L
P
S
G
R
A
P
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.5
99
91.1
N.A.
92.1
91
N.A.
N.A.
77.4
67.7
65.9
N.A.
25.5
N.A.
N.A.
26.5
Protein Similarity:
100
85.6
99.5
94.4
N.A.
94.4
93.6
N.A.
N.A.
87.4
79
77.4
N.A.
39.9
N.A.
N.A.
40.7
P-Site Identity:
100
13.3
93.3
0
N.A.
0
0
N.A.
N.A.
0
13.3
0
N.A.
13.3
N.A.
N.A.
6.6
P-Site Similarity:
100
13.3
93.3
6.6
N.A.
6.6
6.6
N.A.
N.A.
20
26.6
13.3
N.A.
40
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
0
0
0
0
10
0
0
0
0
19
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
19
0
10
0
0
0
0
0
19
0
19
0
% D
% Glu:
10
0
10
37
10
0
37
19
0
10
0
0
19
10
19
% E
% Phe:
0
0
0
19
0
0
0
0
19
10
0
0
0
0
0
% F
% Gly:
0
0
19
0
0
0
0
0
0
0
28
28
0
0
19
% G
% His:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% I
% Lys:
19
10
10
0
0
19
0
0
10
0
0
10
0
0
10
% K
% Leu:
0
0
0
0
0
0
0
19
10
0
0
0
19
0
10
% L
% Met:
0
10
0
0
0
0
0
0
19
0
19
0
0
0
0
% M
% Asn:
28
0
0
0
28
0
0
0
0
19
10
0
0
10
0
% N
% Pro:
19
10
19
10
19
28
10
10
37
19
19
0
10
28
10
% P
% Gln:
0
10
10
0
10
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
19
0
0
10
10
10
0
10
0
0
10
0
19
19
% R
% Ser:
0
0
28
0
19
10
10
37
0
28
10
0
10
0
0
% S
% Thr:
19
0
0
0
10
19
0
0
0
19
10
10
19
0
0
% T
% Val:
0
28
0
10
0
0
19
10
0
0
10
0
10
0
19
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
19
0
% W
% Tyr:
0
10
0
0
0
0
19
0
0
0
0
28
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _